QLF-D와 OCT를 이용한 초기 인공우식병소의 변화 탐지
Detection of early changes in caries lesion using QLF-D and OCT
구혜민, 김보라, 강시묵, 정중호, 권호근, 김백일,
소속 상세정보
구혜민 ( Ku Hye-Min ) - 연세대학교 치과대학 예방치과학교실
김보라 ( Kim Bo-Ra ) - 연세대학교 치과대학 예방치과학교실
강시묵 ( Kang Si-Mook ) - 연세대학교 치과대학 예방치과학교실
정중호 ( Chung Jung-Ho ) - LG전자 미래 IT 융합연구소
권호근 ( Kwon Ho-Keun ) - 연세대학교 치과대학 예방치과학교실
김백일 ( Kim Baek-Il ) - 연세대학교 치과대학 예방치과학교실
KMID : 0355420140380010010
Abstract
Objectives: We aimed to compare the differences in caries lesion changes when measured by QLF-Das fluorescence loss and by SS-OCT as lesion depth with respect to demineralized time, duringformation of artificial early caries lesion. We also demonstrated that QLF-D and SS-OCT can be usedeffectively in monitoring the longitudinal progression of simulated caries lesions.
Methods: Ten bovine incisors were sectioned (5×4 mm) and embedded in epoxy resin. An acidresistantnail varnish was applied to a part of the tooth surfaces to protect sound enamel (2×4 mm). Togenerate lesions, each specimen was immersed in 40 ml of a demineralizing gel for 20 days at 37oC.To measure mineral loss of the demineralized specimens, fluorescence loss (ΔF, %) was measured byQLF-D and lesion depth (μm) was determined by SS-OCT from the captured cross-sectional image.All the specimens were analyzed daily by QLF-D image analysis software and SS-OCT image analysisprogram for 20 days. The repeated measures analysis of ΔF and lesion depth was used. The pairedt-test was used to assess differences between each day. The correlation between ΔF and lesion depthwas determined using the Pearson’s correlation coefficient.
Results: On the 5th, 10th, and 15th day, compared to baseline values, ΔF decreased in 12.7%, 25.0%,and 33.6% of the specimens, respectively, and the lesion depth increased in 9.9%, 16.0%, and 22.6%of the specimens, respectively. However, after 15 days, there was no change in the ΔF and lesiondepth. High significant correlation was identified between the resultant values of ΔF obtained by QLF-Dand those of lesion depth obtained by SS-OCT (r = ―0.811, P<0.0001).
Conclusions: The QLF-D and SS-OCT could detect subtle changes in mineral loss and lesion depthwith respect to demineralized time. Furthermore, these devices were useful for monitoring changes inmineral amount and lesion depth.
키워드
Early dental caries; Longitudinal study; Optical coherence tomography; Quantitative light-induced fluorescence-digital
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